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Index > Protein center > Gja1(Gene name) > Mouse
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  • Gja1 (Gene name),
  • Gap junction alpha-1 protein (Protein name ),  CXA1_MOUSE from NCBI database.
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  • Gene name:
    Gja1(Cxn-43);
    Protein name:
    Gap junction alpha-1 protein;
    Alternative:
    Gap junction 43 kDa heart protein;Connexin-43(Cx43);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    A connexon is composed of a hexamer of connexins. Interacts with SGSM3. Interacts with KIAA1432/CIP150 (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain) (By similarity). Interacts with CNST.
    Function:
    Connexin 43 is possibly the ATP-induced pore of mouse macrophages.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cell junction gap junction
    Protein Attributes:
    Sequence length:
    382
    Sequence:
    50:
    MGDWSALGKL | LDKVQAYSTA | GGKVWLSVLF | IFRILLLGTA | VESAWGDEQS | 
    100:
    AFRCNTQQPG | CENVCYDKSF | PISHVRFWVL | QIIFVSVPTL | LYLAHVFYVM | 
    150:
    RKEEKLNKKE | EELKVAQTDG | VNVEMHLKQI | EIKKFKYGIE | EHGKVKMRGG | 
    200:
    LLRTYIISIL | FKSVFEVAFL | LIQWYIYGFS | LSAVYTCKRD | PCPHQVDCFL | 
    250:
    SRPTEKTIFI | IFMLVVSLVS | LALNIIELFY | VFFKGVKDRV | KGRSDPYHAT | 
    300:
    TGPLSPSKDC | GSPKYAYFNG | CSSPTAPLSP | MSPPGYKLVT | GDRNNSSCRN | 
    350:
    YNKQASEQNW | ANYSAEQNRM | GQAGSTISNS | HAQPFDFPDD | SQNAKKVAAG | 
    382:
    HELQPLAIVD | QRPSSRASSR | ASSRPRPDDL | EI
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    E2241r
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    96T
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    ELISA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    E2241b
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    96T
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    ELISA Kit for Mouse Gap junction alpha-1 protein
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    E2241p
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    ELISA Kit for Mouse Gap junction alpha-1 protein
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    E2241h
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    ELISA Kit for Mouse Gap junction alpha-1 protein
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    E2241c
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    ELISA Kit for Mouse Gap junction alpha-1 protein
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    ELISA Kit for Mouse Gap junction alpha-1 protein
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    E2241d
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    ELISA Kit for Mouse Gap junction alpha-1 protein
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    E2241m
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    CLIA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    U2241r
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    96T
    CLIA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    U2241c
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    96T
    CLIA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    U2241h
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    96T
    CLIA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    U2241b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Gap junction alpha-1 protein
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    U2241p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    U2241d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Gap junction alpha-1 protein
    Cat.:
    U2241m
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    Packing:
    96T
    Polyclonal Antibody for Mouse Gap junction alpha-1 protein
    Polyclonal Antibody for Mouse Gap junction alpha-1 protein
    Polyclonal Antibody for Mouse Gap junction alpha-1 protein
    Cat.:
    P2241Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Gap junction alpha-1 protein
    Polyclonal Antibody for Mouse Gap junction alpha-1 protein
    Polyclonal Antibody for Mouse Gap junction alpha-1 protein
    Polyclonal Antibody for Mouse Gap junction alpha-1 protein
    Cat.:
    P2241Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Gap junction alpha-1 protein
    Cat.:
    P2241Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Gap junction alpha-1 protein
    Monoclonal Antibody for Mouse Gap junction alpha-1 protein
    Monoclonal Antibody for Mouse Gap junction alpha-1 protein
    Monoclonal Antibody for Mouse Gap junction alpha-1 protein
    Monoclonal Antibody for Mouse Gap junction alpha-1 protein
    Monoclonal Antibody for Mouse Gap junction alpha-1 protein
    Monoclonal Antibody for Mouse Gap junction alpha-1 protein
    Monoclonal Antibody for Mouse Gap junction alpha-1 protein
    Protein for Mouse Gap junction alpha-1 protein
    Protein for Mouse Gap junction alpha-1 protein
    Protein for Mouse Gap junction alpha-1 protein
    Protein for Mouse Gap junction alpha-1 protein
    Protein for Mouse Gap junction alpha-1 protein
    Protein for Mouse Gap junction alpha-1 protein
    Protein for Mouse Gap junction alpha-1 protein
    Protein for Mouse Gap junction alpha-1 protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages."
      Beyer E.C. , Steinberg T.H.
      J. Biol. Chem.266:7971-7974(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Developmental regulation of gap junction gene expression during mouse embryonic development."
      Nishi M. , Kumar N.M. , Gilula N.B.
      Dev. Biol.146:117-130(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: CD-1.
      tissue: Ovary.
    3. 3.
      "Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung."
      Hennemann J. , Suchyna T. , Lichtenberg-Frate H. , Jungbluth S. , Dahl E. , Schwarz J. , Nicholson B.J. , Willecke K.
      J. Cell Biol.117:1299-1310(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: C57BL/6.
    4. 4.
      "Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43."
      Sullivan R. , Ruangvoravat C. , Joo D. , Morgan J. , Wang B.L. , Wang X.K. , Lo C.W.
      Gene130:191-199(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE
      tissue: Embryo.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Blastocyst.
      tissue: Head.
      tissue: Lung.
      tissue: Vagina.
    6. 6.
      "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L. , Muenstermann E. , Schatten R. , Henze S. , Bohn E. , Mollenhauer J. , Wiemann S. , Schick M. , Korn B.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary gland.
    9. 9.
      "Changes in the expression of connexin 43, a cardiac gap junctional protein, during mouse heart development."
      Fromaget C. , el Aoumari A. , Dupont E. , Briand J.-P. , Gros D.
      J. Mol. Cell. Cardiol.22:1245-1258(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 10.
      "Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness."
      Liu X.Z. , Xia X.J. , Adams J. , Chen Z.Y. , Welch K.O. , Tekin M. , Ouyang X.M. , Kristiansen A. , Pandya A. , Balkany T. , Arnos K.S. , Nance W.E.
      Hum. Mol. Genet.10:2945-2951(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    11. 11.
      "Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation."
      Lan Z. , Kurata W.E. , Martyn K.D. , Jin C. , Lau A.F.
      Biochemistry44:2385-2396(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SGSM3
    12. 12.
      "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
      Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain cortex.
    13. 13.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-247;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    14. 14.
      "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
      del Castillo F.J. , Cohen-Salmon M. , Charollais A. , Caille D. , Lampe P.D. , Chavrier P. , Meda P. , Petit C.
      Hum. Mol. Genet.19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CNST
    15. 15.
      "Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall."
      Straub A.C. , Billaud M. , Johnstone S.R. , Best A.K. , Yemen S. , Dwyer S.T. , Looft-Wilson R. , Lysiak J.J. , Gaston B. , Palmer L. , Isakson B.E.
      Arterioscler. Thromb. Vasc. Biol.31:399-407(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION AT CYS-271
    16. 16.
      "Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm."
      Negoro H. , Kanematsu A. , Doi M. , Suadicani S.O. , Matsuo M. , Imamura M. , Okinami T. , Nishikawa N. , Oura T. , Matsui S. , Seo K. , Tainaka M. , Urabe S. , Kiyokage E. , Todo T. , Okamura H. , Tabata Y. , Ogawa O.
      Nat. Commun.3:809-809(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
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